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Angelia D. Lockett, PhD

Angelia_Lockett.jpg

Angelia D. Lockett, PhD
Assistant Research Professor
Department of Cellular & Integrative Physiology
Indiana University School of Medicine
635 Barnhill Drive, MS 313
Indianapolis, Indiana 46202-5120 E-mail: anlocket@iu.edu

Phone:  317-274-1443
Facsimile: 317-274-3318

Education/Training

2001, B.S. Jackson State University, Jackson, MS
2008, PhD Indiana University, Indianapolis, IN
2008, Fellow Indiana University, Indianapolis, IN  

 

Research Biography Summary

Personal Statement

During my graduate studies, my research focus was primarily cell signaling in inflammation. We discovered that a single protein was able to integrate three distinct signaling pathways that regulate the acute innate immune response. I learned to use deductive thinking and analysis of the literature to formulate hypotheses and discover new functions of molecules. My postdoctoral training in Dr. Irina Petrache’s laboratory built on those skills by allowing me to integrate the knowledge of protein biochemistry and signaling pathways exploration to investigating diseases that are relevant to human health.

We were particularly interested in understanding the mechanisms by which emphysema develops, in order to identify novel therapeutic targets to improve outcomes for this deadly disease. Our work was based on the discovery that the most well-known lung protective protein, the serine protease inhibitor A1AT, has functions that extend beyond inhibition of neutrophil elastase. My postdoctoral work contributed to the novel reports that A1AT inhibits the self-perpetuating signaling of TNF-alpha in endothelial cells that may contribute to chronic inflammation, that A1AT inhibits endothelial cell apoptosis via inhibition of executioner caspases and that A1AT can be actively transcytosed across the pulmonary endothelium to mediate its protective effects in the lung epithelium and interstium. In addition to this, we have recently published work demonstrating active uptake and secretion of A1AT by the pulmonary endothelium toward the basolateral aspect of the pulmonary epithelium. As an Assistant Research Professor, I plan to apply my expertise studying A1AT protective effects in the lung to elucidating the mechanisms that contribute to asthma development and exacerbations with the ultimate goal of determining if A1AT augmentation is of therapeutic benefit in the airway. Pursuing this understudied area of research will allow me to carve a niche from which I will build an independent research career.  

Contribution to Science

635 Barnhill Drive, Medical Science Bldg. Room 385 | Indianapolis, IN 46202-5120 | 317-274-7772