Rodney Rhoades, Ph.D.

Photo of Dr. Rhoades  

Professor Emeritus, Retired: Feb. 2003
Former Chairman

Department of Cellular & Integrative Physiology
Indiana University School of Medicine
635 Barnhill Drive
Indianapolis, Indiana 46202-5120

E-mail: rrhoades @
Phone: N/A
Facsimile: 317-274-3318


Our laboratory is interested in the mechanical, biochemical and molecular consequences of hypoxia on smooth muscle in the lung.

Recent Publications


Jin N, Packer CS and Rhoades RA.  Inositol triphosphate is involved in norepinephrine- but not in hypoxia-induced pulmonary artery contraction.
Am J Physiol Lung Cell Mol Physiol 264: L160-L164, 1993.

Zhao Y, Packer CS and Rhoades RA.  Pulmonary vein contracts in response to hypoxia.
Am J Physiol Lung Cell Mol Physiol 265: L87-L92, 1993.


Packer CS, Bennie RE, Powell DR and Rhoades RA.  Neonatal hypoxia: Long term effects on pulmonary arterial muscle.
Respir Physiol 96: 213-229, 1994. PubMed

Griffith SL, Rhoades RA and Packer CS.  Pulmonary arterial smooth muscle contractility in hypoxia-induced pulmonary hypertension.
J. Appl. Physiol. 77: 406-414, 1994.

Roepke DA, Griffith SL, Meiss RA, Rhoades RA, Packer CS.  Contractility and myosin heavy chain isoform patterns in developing tracheal muscle.
Respir Physiol 98(1): 101-110, Sep 1994. PubMed


Zhao Y, Packer CS and Rhoades RA.  Chronic hypoxia impairs pulmonary venous smooth muscle contraction.
Respir. Physiol. 100: 75-82, 1995. IngentaConnect, PubMed


Rhoades RA, Jin N, Patterson CE, Roepke DA and Packer CS.  Oxidant stress alters signaling mechanisms in pulmonary arterial smooth muscle.
In: Nitric Oxide and Radicals in the Pulmonary Vasculature. Weir, Archer, and Reeves, (Eds.) Chapter 17, 265-287. Futura Publishing Co., New York, NY, 1996.

Zhao Y, Rhoades RA and Packer CS.  Hypoxia-induced pulmonary arterial contraction appears to be dependent on myosin light chain phosphorylation.
Am J Physiol Lung Cell Mol Physiol 271: L768-L774, 1996.

Jin N, Siddiqui RA, English D and Rhoades RA.  Communication between tyrosine kinase pathway and myosin light chain kinase pathway in smooth muscle.
Am J Physiol Heart Circ Physiol 271: H1348-H1355, 1996.


Jin N and Rhoades RA.  Activation of tyrosine kinase by H2O2-induced contraction in pulmonary artery.
Am J Physiol Heart Circ Physiol 272: H2686-H2692, 1997.

Wagner RS, Smith CJ, Taylor AM and Rhoades RA.  Phosphodiesterase inhibition improves relaxation in hypertensive pulmonary arteries.
J Pharm Exp Therap 282: 1650-1657, 1997.

Wagner RS, Weare C, Jin N, Mohler ER and Rhoades RA.  Characterization of signal transduction events stimulated by 8-epi-prostaglandin(PG)F2 alpha in the rat aortic rings.
Prostaglandins 54: 581-599, 1997. PubMed


Zhang J, Jin N and Rhoades RA.  Hydrogen peroxide stimulates extracellular signal-regulated protein kinases in pulmonary arterial smooth muscle cells.
Am J Respir Cell Mol Biol 19(2): 324-332, 1998.

Packer CS, Roepke JE, Oberlies NH and Rhoades RA.  Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial muscle.
Am J Physiol Lung Cell Mol Physiol 274: L775-85, 1998.


Jin N, Hatton N, Swartz DR, Xia X, Harrington MA, Larsen SH, and Rhoades RA.  Hypoxia activates Jun-N-terminal kinase (JNK), extracellular signal-regulated protein kinase (ERK), and p38 kinase in pulmonary arteries.
Am J Respir Cell Mol Biol, Volume 23, Number 5, 593-601, November, 2000.


Wang Z, Jin N, Ganguli G, Swartz DR, Li L, and Rhoades RA.  Rho-Kinase Activation Is Involved in Hypoxia-Induced Pulmonary Vasoconstriction.
Am J Respir Cell Mol Biol, Volume 25, Number 5, 628-635, November 2001.


Boguslawski G, Grogg JR, Welch Z, Ciechanowicz S, Sliva D, Kovala AT, McGlynn P, Brindley DN, Rhoades RA, English D.  Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response.
Exp Cell Res 274(2):264-274, Apr 2002. PubMed


Wang Z, Lannér MC, Jin N, Swartz DR, Li L, and Rhoades RA.  Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells.
Am J Respir Cell Mol Biol, Volume 29, Number 4, 465-471, 2003.


Lannér MC, Raper M, Pratt WM, Rhoades RA.  Heterotrimeric G proteins and the platelet-derived growth factor receptor-β contribute to hypoxic proliferation of smooth muscle cells.
Am J Respir Cell Mol Biol. Oct;33(4): 412-419, 2005. Reprint, PubMed

Last update: 2/26/2010



1961; Miami University, Oxford, Ohio. Zoology
1966; Ohio State University, Columbus, Ohio. Ph.D. in Physiology
1966-1971; Assistant Professor, Pennsylvania State Univ.
1971-1975; Associate Professor, Pennsylvania State Univ.
1975-1976; Research Scientist, National Heart and Lung Institute (Dr. Ronald Crystal's Laboratory)
1976-1978; Associate Professor, Indiana Univ. School of Medicine
1978-1981; Professor, Indiana Univ. School of Medicine
1981-2003; Chairman, Dept of Cellular & Integrative Physiology, Indiana Univ. School of Medicine


Beta, Beta, Beta, (1961), NASA Fellowship (1964-1966), Research Career Development Award (1976-1981)

Memberships and Offices in Professional Societies

American Physiology Society; Biophysical Society; American Heart Association; American Thoracic Society; American Association for the Advancement of Science; Sigma Xi; Editorial Board: American Journal Physiology: Lung Cellular and Molecular Physiology

National Committees

Planning Committee, American Physiological Society (1971), National Institutes of Health, PulmonaryAdvisory Committee (1976-1980), National Institutes of Health Study Section (regular member Heart & Lung SS A, 1972-1976. Ad hoc or special section member; 1976-1978, 1985, 1988, 1992), American Lung Association/American Thoracic Society Research Review Committee, 1981-1986, Pulmonary Advisory Committee, American Heart (1981-present), National Board of Medical Examiners (Chaired Comprehensive Pulmonary Task Force Committee, 1988-1990; Pathophysiology Task Force, 1992-1994; Physiology Committee, 1994-present)

 Feb. 2003

635 Barnhill Drive, Medical Science Bldg. Room 385 | Indianapolis, IN 46202-5120 | 317-274-7772