Simon Rhodes, Ph.D.
Professor and Associate Dean for Graduate Studies
Department of Cellular & Integrative Physiology
Graduate program affiliations
- Cellular and Integrative Physiology
- Biochemistry and Molecular Biology
- Medical Neuroscience
Education / Training
- 1984, B.Sc., University of Sheffield, United Kingdom
- 1991, Ph.D., Purdue University, West Lafayette, Indiana
- 1995, Postdoctoral Fellowship, University of California at San Diego, California
Molecular basis of pediatric combined pituitary hormone deficiency diseases
Our laboratory investigates how key regulatory genes direct the determination and differentiation of individual endocrine cell lineages during vertebrate development. The mature anterior pituitary gland contains five discrete cell types that are each characterized by the secretion of specific polypeptide hormones critical for growth, sexual function, lactation, thyroid activity, adrenal physiology, and homeostasis. We use both molecular/in vitro and transgenic animal approaches to examine the roles of several classes of transcription factors in the specification of pituitary cell phenotypes. Our research goals include:
- Characterization of the molecular genetic pathways by which transcription factors control the development and physiology of the pituitary gland.
- Investigation of the molecular nature of human pituitary diseases, such as combined pituitary hormone deficiency (CPHD) diseases in children and pituitary tumors. These studies involve collaboration with faculty at Children's Hospital, Leipzig, Germany; Riley Children's Hospital in Indianapolis; Maimonides Hospital Brooklyn, NY, and other hospitals.
- The analysis of the gene regulatory pathways that control growth, metabolism and reproductive fitness in agricultural species, in collaboration with the U.S. Meat Animal Research Center.
Grant Funding: NIH-NICHD; NSF.
Rhodes' Research Laboratory Home Page
Table of contents:
- Research Overview
- Research Goals
- Lab Members
- Techniques Database
Last update: 5/15/2009