Mission Statement


Create an environment fostering outstanding research and teaching by our commitment to obtaining and imparting knowledge of molecular, cellular, and integrative physiology.


Intravital microscopy (IVM) measurements of the response of the protein kinase A (PKA) biosensor AKAR4.1 to glucagon in hepatocytes in the intact mouse liver.  The PKA biosensor was introduced into mice by tail vein injection of an adenoviral vector, resulting in extensive expression of AKAR4.1 in the liver after 7 days.  Mice were fasted for 3 hrs prior to intrapertoneal injection of glucagon (200ug/kg) followed by IVM.  (A) The background-corrected Venus to Turquoise FP emission ratios were monitored from 10 individual cells (+SE) over 10 minutes demonstrating the robust activation of PKA in response to glucagon.  (B) Ratio images from a single image plane in mouse liver at the indicated time points (scale bar is 10 um).  Tao et al. (2015) Am J Physiol Cell Physiol. Sep 2



to the Department of Cellular & Integrative Physiology Home page. We invite you to use this site as a resource to explore our department. If you are considering applying to our graduate program, please explore the related links to learn about the breadth and depth of our Ph.D. and M.S. programs. We also encourage you to explore the research interests of our faculty in more detail using the links on this page. The Department is within the Indiana University School of Medicine. 

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