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Course Descriptions

Complete List of Current Physiology (PHSL) and Graduate (GRAD) Course Listings for Physiology Students

PHSL F503 HUMAN PHYSIOLOGY (Fall; 5 cr.) Graduate level course in human physiology designed for students with no prior exposure to the discipline. Emphasis on basic physiological mechanisms of control with regard to membrane, neural, endocrine, reproductive, muscle, cardiovascular, respiratory, gastrointestinal, renal, and multisystems physiology.

PHSL F505 Solving Clinical Problems (Spring; 2 cr) Physiology course for graduate students (M.S. and Ph.D.) providing an opportunity to "solve" medical cases using simulated patient discussions and laboratory results. Students will be given real-life patient dialogs and laboratory test results to interpret and develop potential diagnoses and treatments.

PHSL F595 ADVANCED PHYSIOLOGY (hrs. and cr. arr.) Discussions and literaterature research in advanced areas of physiology.

PHSL F701 RESEARCH IN PHYSIOLOGY (cr. arr.) This course provides credit hours for laboratory rotations and independent research effort. For rotations, students consult with program faculty and select up to 3 laboratories in which students rotate for a minimum of 5 weeks each to perform laboratory research.

PHSL F702 SEMINAR IN PHYSIOLOGY (1 cr.) Invited international, national, and local speakers present recent studies. Interactive with question and answer period.

PHSL F780: SPECIAL TOPICS IN PHYSIOLOGY (hrs. and cr. arr.)  Tutorial instruction in physiology.

GRAD G640: EPITHELIAL CELL BIOLOGY (hrs. arr.; 1 cr.) P: Graduate level cell biology course. The course is an integrated approach to studying the structure and functional relationships in epithelial cells, the role of this subcellular organization in normal physiology, and the disturbances that underlie pathophysiology. The emphasis is on reading and discussion of original review articles and research papers, and demonstrations of techniques to study epithelial functions in cultured cells, tissues and model organisms such as the zebrafish.

GRAD G703: PHYSIOLOGY OF THE CORONARY CIRCULATION (hrs arr.; 1 cr) P: Graduate level physiology course. Advanced study of the physiology, pharmacology, and pathophysiology of the coronary circulation using contemporary methods is emphasized. Concepts of hemodynamics, cardiac regulation, vasomotor control, pressure pulses, etc. are reinforced. In vivo studies using angiography, intravascular ultrasound, coronary flow velocity measures, coronary angioplasty, and echocardiography in large animal models are compared with in vitro methods. An overall goal is to provide a rational basis for functional genomics and modern therapy. Approach will be the use of current textbooks, select reviews, original research papers, interactive discussion, and laboratory demonstrations and projects.

GRAD G704: PHYSIOLOGICAL PROTEOMICS (hrs. arr.; 1 cr.) P: Graduate level biochemistry course. This is a fundamentals-based course on theory and practice of contemporary pro techniques. Graduate students will learn to select and applyappropriate proteomic technologies in their research through exposure to protein analytical, quantitative, and informatic approaches to physiologically relevant biomedical problems.

GRAD G706: DESIGNER MICE - TRANSGENES AND KNOCKOUT ANIMALS (hrs. arr.; 1 cr.) P: Graduate level cell and molecular biology courses. An advanced course emphasizing the strategies for designing genetically modified mouse models. The approach will involve study of the components of vectors, experimental methods to generate these animals, and approaches to studying these animals. This course will use a combination of readings, discussions and problem sets related to generating, breeding and analyzing transgenic and knockout mice.

GRAD G707: PHYSIOLOGY OF THE SMOOTH MUSCLE (hrs. arr.; 1 cr.) P: Graduate level physiology and cell biology courses. Advanced study of the physiology of the smooth muscle tissues with focus on the normal physiology and pathophysiology of airway smooth muscle and the airways. Biochemical and physiologic mechanisms in the regulation of contraction, growth, and phenotypic expression in smooth muscle tissues will be explored. Focus will be on contemporary molecular and cellular and whole animal approaches for the study of muscle physiology, including tissue transfection and the genetic modification of smooth muscle tissues, organ culture, and methods for the measurement of contractility and contractile protein activation in intact and permeabilized tissues including confocal imaging, and in vivo measurement of airway function.

GRAD G708: CARDIAC AND CORONARY PHYSIOLOGY OF EXERCISE (hrs. arr.; 1 cr.) Given the current epidemic and foreseeable continuing trend of obesity and diabetes in the U.S., emphasis will be placed on responses and adaptations of the heart and coronary circulation to exercise in the setting of obesity- and diabetes-induced coronary disease. Concepts of exercise stimulus, quantification of work, and in vivo responses and adaptations will be fundamental to studies of cellular and molecular mechanisms of myocardial and coronary artery responses and adaptations to exercise. The approach taken will be the use of current textbooks, select reviews, original research papers, interactive discussion, and laboratory demonstrations and projects.

GRAD G712 IN VIVO MICROCIRCULATORY PHYSIOLOGY (hrs. arr.; 1cr.) The fundamental roles of the microcirculation are to provide oxygen and nutrients to the living cells, remove their wastes, and maintain hydration of the tissues. All of these functions are best understood from their cellular and biophysical regulation in the in vivo setting. The course will explore each of the major issues of microcirculatory physiology through reading of original literature, reviews on each subject, and laboratory exercises to observe and manipulate the in vivo microvasculature. The students will also be introduced to the biophysics of measurements of oxygen and nitric oxide as two of the key biomolecules that the microvasculature uses in regulation of blood flow to an organ.

GRAD G713: ANGIOGENESIS (hrs. arr.; 1 cr.) P: Graduate level cell biology course. This course addresses the ability of the body to grow new blood vessels, a process named angiogenesis. Focus will be on concepts and mechanisms of angiogenic processes. The course will start with lectures and workshops covering the basic knowledge of angiogenesis. Methods of assessing angiogenesis in vitro and in vivo will be introduced and also part of laboratory demonstration and independent laboratory experiments. Understanding the mechanisms of angiogenesis is essential in order to identify new therapeutic means to combat diseases, which are caused or linked to abnormal angiogenesis. While excessive angiogenesis occurs in diseases such as cancer, insufficient angiogenesis is characteristic of ischemic tissue.

GRAD G714: DEVELOPMENT OF THE VASCULAR SYSTEM (hrs arr.; 1 cr.) P: Graduate level cell biology course. This advanced level course is offered to graduate students who have an interest in vascular biology. Concepts of vascular development will be explored with an emphasis on the experimental techniques used to unravel organ development. The course will provide an in-depth knowledge of the physiology, cell and molecular biology of the development of the vascular system by means of introductory lectures, assigned reviews of current literature, group discussions and laboratory demonstrations with an emphasis on the experimental techniques used to examine developmental systems. The course will comprise a mixture of didactic lecture, student reading and presentation of original research and review articles, group discussions and laboratory demonstrations. The course will comprise 4 one-hour sessions per week over a 4-week session.

GRAD G735: (Spring; 2 cr) Cardiovascular, Renal and Respiratory Function in Health and Disease P: undergraduate cell biology and biochemistry. Introductory physiology course for graduate students covering fundamental concepts of cellular and integrative physiology of tissues and organ systems. Basic physiology of the musculo-skeletal, cardiovascular, and respiratory systems are covered. At the end of the course, students should have a basic understanding of the physiologic functions of cells, tissues and organ systems and should understand modern approaches for the measurement and interpretation of physiologic functions. (Offered every spring as a modular course in the IBMG gateway program)

GRAD G736: (Spring; 1 cr) Endocrine & Gastrointestinal Function in Health and Disease P: undergraduate cell biology and biochemistry. Introductory physiology course for graduate students covering fundamental concepts of cellular and integrative physiology of tissues and organ systems. Basic physiology of the endocrine, and gastrointestinal systems are covered. At the end of the course, students should have a basic understanding of the physiologic functions of cells, tissues and organ systems and should understand modern approaches for the measurement and interpretation of physiologic functions. (Offered every spring as a modular course in the IBMG gateway program.)

GRAD G761: MOLECULAR AND CELLULAR PHYSIOLOGY OF ION CHANNELS (hrs. arr.; 1cr.) Advanced ion transport topics are selected by students from current areas of research on ion channels, pumps, and exchangers. Specific topics include transporter biophysical characteristics, long-term regulation, effects on cell and organ function, electrophysiological and optical methods for study. Format: textbooks, reviews, original research papers, interactive discussion, computer simulations, and laboratory demonstrations and projects. P: graduate cellular physiology or consent of instructor.

GRAD G762: RENAL PHYSIOLOGY (hrs. arr.; 1 cr.) P: Graduate level physiology course. Students will read and discuss several classical or outstanding research papers in renal physiology. Laboratory experiences will include measurement of renal function using clearance methods and demonstrations of micropuncture and in vivo imaging techniques. The course is intended for graduate students who plan to teach or do research in physiology or related disciplines.

GRAD G782: PHYSIOLOGY & PATHOPHYSIOLOGY OF LIPID RAFTS (hrs. arr.; 1 cr) P: Graduate level cell biology course. The course is targeted to pre-doctoral graduate students in the School of Medicine with interest in advanced study of lipid rafts, a class of membrane domains that compartmentalize signaling molecules and macromolecule complexes to specific cellular sites, and spatially organize signal transduction in cells. The course will reinforce membrane architecture and explore the molecular basis of lipid raft function and dysfunction in disease. The topics to be discussed include: biophysics of lipid lateral organization, biogenesis and maintenance of lipid domains, signal transduction from lipid rafts, and role of lipid rafts in disease. The overall objective is to provide a deep understanding of lipid rafts in membrane organization and cellular function. The course will be comprised of a mixture of didactic lecture, reading and presentation of original research and review articles, group discussion, and laboratory demonstrations.

GRAD G805: DIABETES AND OBESITY (3 cr) Biochemistry, cell biology, molecular biology, genetics, immunology, and pathophysiology of diabetes and obesity. Topics include metabolic regulation, signal transduction, insulin resistance, insulin production, beta-cell function, animal models, complications, nutrition, prevention, and therapy.

GRAD G830: ADVANCED CARDIOVASCULAR PHYSIOLOGY (Fall; 3 cr.) P: Graduate level physiology course. Advanced study of the physiology, pharmacology, and pathophysiology of the cardiovascular system using contemporary methods. Concepts of cardiovascular structure, function, hemodynamics, excitation-contraction coupling, signal transduction, and electrophysiology are reinforced. Format: lectures and facilitated interactive student discussion.

GRAD G831: CONCEPTS & CONTROVERSIES IN CARDIOVASCULAR SCIENCE (Fall; 2 cr.) P: Graduate level physiology course. The focus of this course is topical areas of advanced cardiovascular research, emphasizing modern approaches to study cardiovascular function. Topics will change each semester but may include: regulation of vascular tone, cardiovascular development, control of cardiac function, myopathies, atherosclerosis, and blood pressure. Format: Journal Club/Seminar and facilitated interactive student discussion.

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8/06/2011

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