George Tanner, Ph.D.
Professor Emeritus, Retired: July 2009
E-mail: gtanner @ iupui.edu
Education / Training
- 1959, B.A. in Zoology, Cornell University, Ithaca, New York
- 1964, Ph.D. in Physiology, Harvard University, Cambridge, Massachusetts
- 1964-67, PHS Postdoctoral Fellowship, Cornell University Medical College, New York
I retired July 2009, after 42 years as a faculty member in the Physiology department, and moved to Oregon. My address is 3302 Stoney Ridge Road, Eugene, OR 97405. My research was on kidney function in health and disease. I used mainly kidney clearance and micropuncture techniques on small laboratory animals, and, in my last few years, two-photon microscopy. I believe that a combination of micropuncture techniques with the new sophisticated in vivo imaging methods shows great promise for future research. My research dealt with topics such as tubular reabsorption and secretion of organic compounds, acute kidney injury, ureteral and single nephron obstruction, tubuloglomerular feedback, glomerular permeability, and polycystic kidney disease (PKD). I found that ingestion of alkalinizing citrate salts (e.g., potassium citrate) in rats with PKD resulted in dramatic slowing of the disease; whether this treatment would be beneficial in people with PKD should be studied. My wife, Judith A. Tanner, Ph.D., helped me with my research throughout my career.
Selected Recent Publications
Tanner GA, Vijayalakshmi K, and Tanner JA. Effects of potassium citrate/citric acid intake in a mouse model of polycystic kidney disease. Nephron 84:270-273, 2000. Content.Karger.com
Tanner GA and Tanner JA. Citrate therapy for polycystic kidney disease in rats.
Kidney Int 58:1859-1869, 2000.
Tanner GA and Tanner JA. Chronic caffeine consumption exacerbates hypertension in rats with polycystic kidney disease. Am J Kidney Disease 38:1089-1095, 2001. PubMed
Tanner GA, Tielker MA, Connors BA, Phillips CL, Tanner JA, and Evan AP. Atubular glomeruli in a rat model of polycystic kidney disease. Kidney Int 62:1947-1957, 2002.
Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, and Molitoris BA. Functional studies of the kidney of living animals using multi-color two-photon microscopy.
Am J Physiol Cell Physiol 283:C905-916, 2002.
Tanner GA and Tanner JA. Dietary citrate treatment of polycystic kidney disease in rats.
Nephron Physiol 93:14-20, 2003. Content.Karger.com
Rhoades RA and Tanner GA (eds). Medical Physiology, 2nd ed. Baltimore:
Lippincott Williams and Wilkins, 2003.
Tanner GA, Sandoval RM, and Dunn KW. Two-photon in vivo microscopy of sulfonefluorescein secretion in normal and cystic rat kidneys. Am J Physiol Renal Physiol 286:F152-F160, 2004.
Tanner JA and Tanner GA. Dietary potassium citrate does not harm the pcy mouse.
Exp Biol Med 230:57-60, 2005.
Tanner GA, Sandoval RM, Molitoris BA, Bamburg JR, and Ashworth SL. Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney.
Am J Physiol Renal Physiol 289:F638-F643, 2005.
Ashworth SL and Tanner GA. Fluorescent labeling of renal cells in vivo.Månsson LE, Melican K, Boekel J, Sandoval RM, Hautefort I, Tanner GA, Molitoris BA, and Richter-Dahlfors A. Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals. Cell. Microbiol. 9(2):413-424, 2007. Wiley InterScience
Nephron Physiology 103:91-96, 2006. Content.Karger.com
Ashworth SL, Sandoval RM, Tanner GA, and Molitoris BA. Two-photon microscopy: Visualization of kidney dynamics. Kidney Int, 72:416-421, 2007.
Melican K, Boekel J, Månsson LE, Sandoval RM, Tanner GA, Källskog Ö, Palm F, Molitoris BA, Richter-Dahlfors A. Bacterial infection mediated mucosal signaling induces local renal ischemia as a defense against sepsis. Cellular Microbiology, 10:1987-1998, 2008. Wiley InterScience
Honors and Society Memberships
- Phi Beta Kappa
- Amoco Foundation Award for Distinguished Teaching at Indiana University
- Member of American Physiological Society, American Society of Nephrology, International Society of Nephrology, Polycystic Kidney Research Foundation, Sigma Xi
- Excellence in Teaching Award, spring 2006 (First year medical students, class of 2009)
- 2002, 2005, 2008 Indiana University Trustees Awards for Teaching
- 2009 Indiana University School of Medicine Faculty Teaching Award
Last update: 2/12/2010