Jim (Vuchetich) Byrd
Coworker in Sturek Lab
Department of Cellular & Integrative Physiology
Indiana University School of Medicine
635 Barnhill Drive, Room 366
Indianapolis, Indiana 46202-5120
E-mail: jvucheti @ iupui.edu
Phone: (317) 278-3711
Facsimile: (317) 274-3318
My work involves three primary functions, Anesthesiology, Pathology & Surgery. I endeavor to minimize any stress or discomfort that our subjects may experience through medical intervention. During surgeries, I provide access to the femoral artery, which allows us to study the coronary system in vivo. After research tissue has been obtained, I process and prepare it for histology. The resulting microscope slides provide a wealth of information regarding the disease state of our animals. Below is a sample of one such slide, showing collagen (blue-green) contained amongst the smooth muscle cells (red) of a coronary artery.
Early changes in the arterial structure can be detected and quantified, which may help our understanding of atheroschlerosis and methods to inhibit or reduce this process.
Dixon, J.L., S. Shen, J.P. Vuchetich, E. Wysocka, G. Sun, and M. Sturek. Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profile. J. Lipid Res. 43: 1618-1629, 2002.
Dyson, M.C., M. Alloosh, J.P. Vuchetich, E.A. Mokelke, and M. Sturek. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp. Med. 56: 35-45, 2006. PubMed
Mokelke, E., J.P. Vuchetich, M. Alloosh, K.L. March, S. Kaser, M.N. Zafar, and M. Sturek. Short-term exercise prevents post-stent microvascular dysfunction, progression of macrovascular coronary atheroma, and in-stent remodeling. The FASEB Journal 20: A1396-A1397, 2006.
Sturek, M., E.A. Mokelke, J.P. Vuchetich, J.M. Edwards, M. Alloosh, and K.L. March. In-stent neointimal hyperplasia is less fibrous in metabolic syndrome Ossabaw compared to lean Yucatan swine. The FASEB Journal 20: A1399-A1400, 2006.
Sturek, M., M. Alloosh, J. Wenzel, J.P. Byrd, J.M. Edwards, P.G. Lloyd, J.D. Tune, K.L. March, M.A. Miller, E.A. Mokelke, and I.L. Brisbin, Jr. Ossabaw Island miniature swine: cardiometabolic syndrome assessment. In Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition. M.M. Swindle (Ed.). Ames: Iowa State University Press, pp. 397-402, 2007. [CD supplement includes 28 figures and 44 videos.]
Edwards J.M., Z.P. Neeb, M.A. Alloosh, X. Long, I.N. Bratz, C.R. Peller, J.P. Byrd, S. Kumar, A.G. Obukhov, and M. Sturek. Exercise training decreases store-operated Ca2+ entry associated with metabolic syndrome and coronary atherosclerosis.
Cardiovasc Res 85(3):631-640, Feb 2010. PubMed
Last update: 1/23/2010